Alzheimer?s disease Archimedes condition-event simulator: development and
validation 
   Lead Investigator:    Ali Tafazzoli
   Institution      :    Evidera
   E-Mail           :    ali.tafazzoli@evidera.com
   Proposal ID      :    988



   Proposal Description:
   Several advances have been made in Alzheimer?s disease (AD) modeling, however, there remains a need for a simulator that represents the full scope of disease progression that can be used to study new disease-modifying treatments (DMTs) for early-stage and even prodromal AD. To meet this need, we are developing AD ACE, a patient-level simulator with a focus on simulating the effects of early interventions through changes in biomarkers of AD. The AD ACE permits modeling of treatments ranging from very early disease modification to symptomatic treatments in advanced disease.